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signal-averaged ecg mouse saecg v1.2 program  (ADInstruments)


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    ADInstruments signal-averaged ecg mouse saecg v1.2 program
    <t>ECG</t> tracings of one wild-type (WT) and two transgenic (TG) mice. A: WT mouse, RR 117 ms, basal heart rate (HR) 513 bpm, QT 60 ms. B: TG Mouse, RR 119 ms, basal HR 506 bpm, QT 74 ms. C: TG mouse, 6 minutes after 0.5 mg/kg carbachol intraperitoneal. A and B illustrate the longer QT interval, for the same HR, present in TG vs WT mice. C shows the occurrence of what looks like an episode of torsades de pointes ventricular tachycardia in a TG mouse exposed to carbachol.
    Signal Averaged Ecg Mouse Saecg V1.2 Program, supplied by ADInstruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/signal+average+ecg+%28saecg%29/pmc03882517-29-5-11?v=ADInstruments
    Average 90 stars, based on 1 article reviews
    signal-averaged ecg mouse saecg v1.2 program - by Bioz Stars, 2026-08
    90/100 stars

    Images

    1) Product Images from "Propranolol prevents life-threatening arrhythmias in LQT3 transgenic mice: Implications for the clinical management of LQT3 patients ☆ "

    Article Title: Propranolol prevents life-threatening arrhythmias in LQT3 transgenic mice: Implications for the clinical management of LQT3 patients ☆

    Journal: Heart Rhythm

    doi: 10.1016/j.hrthm.2013.10.029

    ECG tracings of one wild-type (WT) and two transgenic (TG) mice. A: WT mouse, RR 117 ms, basal heart rate (HR) 513 bpm, QT 60 ms. B: TG Mouse, RR 119 ms, basal HR 506 bpm, QT 74 ms. C: TG mouse, 6 minutes after 0.5 mg/kg carbachol intraperitoneal. A and B illustrate the longer QT interval, for the same HR, present in TG vs WT mice. C shows the occurrence of what looks like an episode of torsades de pointes ventricular tachycardia in a TG mouse exposed to carbachol.
    Figure Legend Snippet: ECG tracings of one wild-type (WT) and two transgenic (TG) mice. A: WT mouse, RR 117 ms, basal heart rate (HR) 513 bpm, QT 60 ms. B: TG Mouse, RR 119 ms, basal HR 506 bpm, QT 74 ms. C: TG mouse, 6 minutes after 0.5 mg/kg carbachol intraperitoneal. A and B illustrate the longer QT interval, for the same HR, present in TG vs WT mice. C shows the occurrence of what looks like an episode of torsades de pointes ventricular tachycardia in a TG mouse exposed to carbachol.

    Techniques Used: Transgenic Assay



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    Image Search Results


    ECG tracings of one wild-type (WT) and two transgenic (TG) mice. A: WT mouse, RR 117 ms, basal heart rate (HR) 513 bpm, QT 60 ms. B: TG Mouse, RR 119 ms, basal HR 506 bpm, QT 74 ms. C: TG mouse, 6 minutes after 0.5 mg/kg carbachol intraperitoneal. A and B illustrate the longer QT interval, for the same HR, present in TG vs WT mice. C shows the occurrence of what looks like an episode of torsades de pointes ventricular tachycardia in a TG mouse exposed to carbachol.

    Journal: Heart Rhythm

    Article Title: Propranolol prevents life-threatening arrhythmias in LQT3 transgenic mice: Implications for the clinical management of LQT3 patients ☆

    doi: 10.1016/j.hrthm.2013.10.029

    Figure Lengend Snippet: ECG tracings of one wild-type (WT) and two transgenic (TG) mice. A: WT mouse, RR 117 ms, basal heart rate (HR) 513 bpm, QT 60 ms. B: TG Mouse, RR 119 ms, basal HR 506 bpm, QT 74 ms. C: TG mouse, 6 minutes after 0.5 mg/kg carbachol intraperitoneal. A and B illustrate the longer QT interval, for the same HR, present in TG vs WT mice. C shows the occurrence of what looks like an episode of torsades de pointes ventricular tachycardia in a TG mouse exposed to carbachol.

    Article Snippet: Measurements were performed using the signal-averaged ECG (mouse SAECG v1.2 program, AD Instruments) through a template-matching algorithm.

    Techniques: Transgenic Assay

    (A) Congenic mice carrying the AKR/J green haplotype in a DBA/2J genetic background display the green haplotype PR interval duration. Overexpression of tagged hTNNI3k in a DBA/2J background significantly prolongs the PR interval. Colors show the haplotype of each strain at the Tnni3k locus, error bars indicate standard deviations. (B–D) Examples of ECG traces of DBA/2J (B), AKR.DBA. hrtfm2 congenic (C) and DBA/2J overexpressing h TNNI3K (D).

    Journal: PLoS Genetics

    Article Title: Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

    doi: 10.1371/journal.pgen.1003113

    Figure Lengend Snippet: (A) Congenic mice carrying the AKR/J green haplotype in a DBA/2J genetic background display the green haplotype PR interval duration. Overexpression of tagged hTNNI3k in a DBA/2J background significantly prolongs the PR interval. Colors show the haplotype of each strain at the Tnni3k locus, error bars indicate standard deviations. (B–D) Examples of ECG traces of DBA/2J (B), AKR.DBA. hrtfm2 congenic (C) and DBA/2J overexpressing h TNNI3K (D).

    Article Snippet: A 3 minute ECG trace was analyzed for HR, and the signal average ECG (SAECG) calculated from each of leads I and II, aligned at QRS maximum, was analyzed for PR duration using the LabChart7Pro software (ADInstruments) and utilized for subsequent QTL mapping.

    Techniques: Over Expression

    Overview of the ECG results mean (st.err) in DBA/2J, DBA.AKR. hrtfm2 and transgenic hTnni3k mice.

    Journal: PLoS Genetics

    Article Title: Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

    doi: 10.1371/journal.pgen.1003113

    Figure Lengend Snippet: Overview of the ECG results mean (st.err) in DBA/2J, DBA.AKR. hrtfm2 and transgenic hTnni3k mice.

    Article Snippet: A 3 minute ECG trace was analyzed for HR, and the signal average ECG (SAECG) calculated from each of leads I and II, aligned at QRS maximum, was analyzed for PR duration using the LabChart7Pro software (ADInstruments) and utilized for subsequent QTL mapping.

    Techniques: Transgenic Assay